This was my wife's and my first trip to Europe from the States; we're geriatrics, in our mid-70s.
While we loved Rome's hustle and bustle, this apartment provided us with a peaceful and quiet escape at the end of our very busy days. It's right across the street from the historic Tiber River, which served as a constant landmark during our travels.
Roberto, our host, was a true gentleman and very personable. The apartment has been in his family for generations. It has all the modern amenities. It is very safe and secure.
Here's what my wife and I loved about the apartment and its location:
a) While being within walking distance of many tourist attractions, it's in a residential area, among local, every-day Romans; away from all those crazy tourists (such as myself and my wife). LOL
b) There are numerous places to eat, in various price-points, along with yummy Gelaterias, close by.
c) The kitchen is well-stocked with cookware and dishware in the event you want to do some cooking or keep some snacks on hand. There are food / liquor stores nearby.
d) Rome has a great bus and rail system, along with inexpensive taxis. Embrace them and don't be intimidated. Single and multiple day travel passes are available at very reasonable prices.
Rome has so much to offer and see; we couldn't do it all in one visit.
God willing, we'll be back in the future, and, hopefully, both Roberto and his lovely apartment, will still be on VRBO.